Prospective analysis of the association between estrogen receptor gene variants and the risk of cognitive decline in elderly women.
Identifieur interne : 004532 ( Main/Exploration ); précédent : 004531; suivant : 004533Prospective analysis of the association between estrogen receptor gene variants and the risk of cognitive decline in elderly women.
Auteurs : Joanne Ryan [Australie] ; Isabelle Carrière ; Helene Amieva ; Olivier Rouaud ; Claudine Berr ; Karen Ritchie ; Pierre-Yves Scarabin ; Marie-Laure AncelinSource :
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [ 1873-7862 ] ; 2013.
Descripteurs français
- KwdFr :
- Femelle, Génotype, Humains, Modèles de hasards proportionnels, Polymorphisme de nucléotide simple (génétique), Questionnaire sur l'état mental de Kahn, Récepteur alpha des oestrogènes (génétique), Récepteur bêta des oestrogènes (génétique), Sujet âgé, Tests neuropsychologiques, Troubles de la cognition (génétique), Vieillissement (génétique), Études d'associations génétiques, Études longitudinales, Études rétrospectives.
- MESH :
- génétique : Polymorphisme de nucléotide simple, Récepteur alpha des oestrogènes, Récepteur bêta des oestrogènes, Troubles de la cognition, Vieillissement.
- Femelle, Génotype, Humains, Modèles de hasards proportionnels, Questionnaire sur l'état mental de Kahn, Sujet âgé, Tests neuropsychologiques, Études d'associations génétiques, Études longitudinales, Études rétrospectives.
English descriptors
- KwdEn :
- Aged, Aging (genetics), Cognition Disorders (genetics), Estrogen Receptor alpha (genetics), Estrogen Receptor beta (genetics), Female, Genetic Association Studies, Genotype, Humans, Longitudinal Studies, Mental Status Schedule, Neuropsychological Tests, Polymorphism, Single Nucleotide (genetics), Proportional Hazards Models, Retrospective Studies.
- MESH :
- chemical , genetics : Estrogen Receptor alpha, Estrogen Receptor beta.
- genetics : Aging, Cognition Disorders, Polymorphism, Single Nucleotide.
- Aged, Female, Genetic Association Studies, Genotype, Humans, Longitudinal Studies, Mental Status Schedule, Neuropsychological Tests, Proportional Hazards Models, Retrospective Studies.
Abstract
A plethora of data suggests a role for estrogen in cognitive function and genetic variants in the estrogen receptors ESR1 and ESR2 have been implicated in a range of hormone-sensitive diseases. It remains unknown however, whether ESR polymorphisms are associated with the risk of decline in specific domains of cognitive function. Data came from 3799 non-demented, community-dwelling elderly women recruited in France to the 3C Study. A short cognitive test battery was administered at baseline and 2, 4 and 7 years follow-up to assess global function, verbal fluency, visual memory, psychomotor speed and executive function. Detailed socio-demographic, behavioral, physical and mental health information was also gathered and genotyping of five common ESR1 and ESR2 polymorphisms was also performed. In multivariable-adjusted Cox analysis, ESR1 rs2234693 and rs9340799 were not significantly associated with the risk of decline on any of the cognitive tasks. However, significant associations with ESR2 polymorphisms were identified. The A allele of rs1256049 was associated with an increased risk of substantial decline in visual memory (HR:1.64, 95% CI: 1.23-2.18, p=0.0007), psychomotor speed (HR:1.43, 95% CI: 1.12-1.83, p=0.004), and on the incidence of Mild Cognitive Impairment (HR:1.31, 95% CI: 1.05-1.64, p=0.02). There was also a weaker association between the A allele of rs4986938 and a decreased risk of decline in psychomotor speed. Our large multicentre prospective study provides preliminary evidence that ESR2 genetic variants may be associated with specific cognitive domains and suggests that further examination of the role of this gene in cognitive function is warranted.
DOI: 10.1016/j.euroneuro.2013.06.003
PubMed: 23932494
Affiliations:
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Electronic address: joanne.ryan@inserm.fr.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Inserm, U1061, Neuropsychiatry: Epidemiological and Clinical Research, Montpellier F-34093, France; Université Montpellier1, Montpellier F-34000, France; Cancer & Disease Epigenetics, Murdoch Children's Research Institute, Flemington Road Parkville, 3052 Victoria</wicri:regionArea><wicri:noRegion>3052 Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name></author><author><name sortKey="Amieva, Helene" sort="Amieva, Helene" uniqKey="Amieva H" first="Helene" last="Amieva">Helene Amieva</name></author><author><name sortKey="Rouaud, Olivier" sort="Rouaud, Olivier" uniqKey="Rouaud O" first="Olivier" last="Rouaud">Olivier Rouaud</name></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></author><author><name sortKey="Scarabin, Pierre Yves" sort="Scarabin, Pierre Yves" uniqKey="Scarabin P" first="Pierre-Yves" last="Scarabin">Pierre-Yves Scarabin</name></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name></author></analytic><series><title level="j">European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology</title><idno type="eISSN">1873-7862</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aging (genetics)</term><term>Cognition Disorders (genetics)</term><term>Estrogen Receptor alpha (genetics)</term><term>Estrogen Receptor beta (genetics)</term><term>Female</term><term>Genetic Association Studies</term><term>Genotype</term><term>Humans</term><term>Longitudinal Studies</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Questionnaire sur l'état mental de Kahn</term><term>Récepteur alpha des oestrogènes (génétique)</term><term>Récepteur bêta des oestrogènes (génétique)</term><term>Sujet âgé</term><term>Tests neuropsychologiques</term><term>Troubles de la cognition (génétique)</term><term>Vieillissement (génétique)</term><term>Études d'associations génétiques</term><term>Études longitudinales</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Estrogen Receptor alpha</term><term>Estrogen Receptor beta</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aging</term><term>Cognition Disorders</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Polymorphisme de nucléotide simple</term><term>Récepteur alpha des oestrogènes</term><term>Récepteur bêta des oestrogènes</term><term>Troubles de la cognition</term><term>Vieillissement</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Genetic Association Studies</term><term>Genotype</term><term>Humans</term><term>Longitudinal Studies</term><term>Mental Status Schedule</term><term>Neuropsychological Tests</term><term>Proportional Hazards Models</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Questionnaire sur l'état mental de Kahn</term><term>Sujet âgé</term><term>Tests neuropsychologiques</term><term>Études d'associations génétiques</term><term>Études longitudinales</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A plethora of data suggests a role for estrogen in cognitive function and genetic variants in the estrogen receptors ESR1 and ESR2 have been implicated in a range of hormone-sensitive diseases. It remains unknown however, whether ESR polymorphisms are associated with the risk of decline in specific domains of cognitive function. Data came from 3799 non-demented, community-dwelling elderly women recruited in France to the 3C Study. A short cognitive test battery was administered at baseline and 2, 4 and 7 years follow-up to assess global function, verbal fluency, visual memory, psychomotor speed and executive function. Detailed socio-demographic, behavioral, physical and mental health information was also gathered and genotyping of five common ESR1 and ESR2 polymorphisms was also performed. In multivariable-adjusted Cox analysis, ESR1 rs2234693 and rs9340799 were not significantly associated with the risk of decline on any of the cognitive tasks. However, significant associations with ESR2 polymorphisms were identified. The A allele of rs1256049 was associated with an increased risk of substantial decline in visual memory (HR:1.64, 95% CI: 1.23-2.18, p=0.0007), psychomotor speed (HR:1.43, 95% CI: 1.12-1.83, p=0.004), and on the incidence of Mild Cognitive Impairment (HR:1.31, 95% CI: 1.05-1.64, p=0.02). There was also a weaker association between the A allele of rs4986938 and a decreased risk of decline in psychomotor speed. Our large multicentre prospective study provides preliminary evidence that ESR2 genetic variants may be associated with specific cognitive domains and suggests that further examination of the role of this gene in cognitive function is warranted.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Amieva, Helene" sort="Amieva, Helene" uniqKey="Amieva H" first="Helene" last="Amieva">Helene Amieva</name><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Rouaud, Olivier" sort="Rouaud, Olivier" uniqKey="Rouaud O" first="Olivier" last="Rouaud">Olivier Rouaud</name><name sortKey="Scarabin, Pierre Yves" sort="Scarabin, Pierre Yves" uniqKey="Scarabin P" first="Pierre-Yves" last="Scarabin">Pierre-Yves Scarabin</name></noCountry><country name="Australie"><noRegion><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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